Analytical Researchers Journal Club @ KCL
This page features a brief description and the accompanying slides for the monthly analytical researchers journal club that takes place at King's College London.
27th October 2017
Presenter: Aminah Ali
Paper: Enge et al. Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns. Cell 2017. Link
Enge et al use single-cell RNA Sequencing to explore somatic patterns of ageing in the Human pancreas. They identify increased transcriptional noise and potential fate drift from older donors, in addition to mutational signatures associated with aging endocrine cells.
29th September 2017
Presenter: Ines Barbosa and Christos Petridis
Paper: Belbin et al. Genetic identification of a common collagen disease in Puerto Ricans via identity-by-descent mapping in a health system. eLife 2017. Link
The paper considers detection of hereditary forms of disease in an Electronic Health Record (EHR)–linked biobank
25th August 2017
Presenters: Ken Hanscombe and Kylie Glanville
Paper: Turley et al. MTAG: Multi-Trait Analysis of GWAS, bioRxiv preprint posted July 3, 2017. Link
MTAG is a method and command line tool for combining GWAS information across multiple correlated traits, with potentially overlapping samples, using only summary level statistics. To the degree that multiple traits are correlated, MTAG increases the power to identify SNPs associated with each trait.